This report summarises the outcome of a Professional Development Course on Introduction to Nuclear Security and Safeguards held by AFRICSIS and CNES at Charleston Hotel Tesano in Accra on 3-7 August and 7-11 December 2015. The course was held to build intellectual capacity and transfer of knowledge, by providing an introduction to the varied principles of nuclear security and safeguards for academic faculty members, research scientists, nuclear reactor technologists, and regulatory officers in Sub-Saharan Africa.